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IN YOUR FERTILITY PROCESS

Advanced analyses to optimize assisted reproduction.

Approximately 15% of infertile men present normal parameters in a standard semen analysis. This is why it is essential to perform additional tests that assess more specific aspects of sperm quality—such as the level of DNA fragmentation in sperm cells.

Sperm DNA fragmentation tests provide crucial information during assisted reproduction processes. They help identify abnormalities that may affect the success rates of techniques such as IVF or ICSI.

Our diagnostic tests offer a more comprehensive evaluation of the male factor, enabling more precise and personalized treatment guidance.

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halosperm® G2 PRO for Men is our flagship product. It offers a fast, simple, and cap-free method to measure sperm DNA fragmentation in just 10 minutes.

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DISCOVER OUR
FERTILITY TESTS

halosperm® G2 PRO for Men is our flagship product. It offers a fast, simple, and cap-free method to measure sperm DNA fragmentation in just 10 minutes.

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Do you need professional help?

We are professionals specialized in the elaboration of fertility kits for men and women. We have a wide network of clinics and professionals with the best resources. You are in good hands.

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  • Phone: (+34) 91 279 69 50
  • General information: info@halotechdna.com
  • Technical support: support@halotechdna.com
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COMMON QUESTIONS
F.A.Q.

Why is the male factor important in fertility treatment?
A couple aged between 29 and 33 with no fertility issues has about a 20–25% chance of conceiving in any given month. After six months of trying, 60% of couples will conceive without medical help. If after one year of unprotected intercourse there is no pregnancy, the couple is considered infertile. The male factor accounts for 34% of infertility cases, while 30% involve both partners. That’s why a thorough semen analysis can help identify potential issues and avoid costly and repeated Assisted Reproduction Treatments (ART).
A standard semen analysis only evaluates sperm concentration, motility, and morphology. This is incomplete, as it does not assess one of the most important parameters: DNA integrity. Also, understanding oxidative stress levels and sperm membrane quality allows for a more accurate diagnosis for reproductive treatment. Around 15% of infertile men have normal semen analysis results.
DNA fragmentation, oxidative stress, and poor sperm vitality are directly linked to lower fertility and embryonic development failures. This leads to more ART cycles required to achieve pregnancy—whether through IUI, IVF, or ICSI—lower embryo quality, and higher rates of miscarriage.
Depending on the levels of DNA fragmentation, oxidation, and sperm vitality, the medical professional will assess the semen sample and, together with the standard semen analysis, determine the best reproductive technique and treatment to improve the chances of success.
Antioxidant treatment can significantly reduce DNA fragmentation levels. The response depends on the root cause—if it’s due to toxic exposure or high temperatures triggering caspases and sperm endonucleases, it’s harder to modify sperm DNA fragmentation levels.
Sperm from the first fraction of the ejaculate typically has lower DNA fragmentation. Recurrent ejaculation or testicular sperm retrieval can also yield similar results depending on the patient. The effectiveness of these strategies should be evaluated by the medical professional.
While semen quality may remain the same across different production and maturation cycles, it can also vary due to external factors like stress, infections, fever, or lifestyle changes. It’s important to assess the ejaculate quality used in ART.
In IUI, pregnancy rates are nearly zero in men with DNA fragmentation levels above 30%. High fragmentation also indicates potential infections (e.g., Chlamydia trachomatis, Mycoplasma) or varicocele. Fragmentation above 30% impacts fertilization and embryo quality, leading to repeated miscarriages and lower reproductive success.
Yes. DNA fragmentation is crucial in selecting the right ART strategy. Studies show that in IUI, fragmentation above 30% lowers the success rate from 19% to 1.5%. Knowing this, alternative techniques can be considered. In IVF, fragmentation below 25% leads to a 33% live birth rate, while over 50% drops that to 13%.

halotech® offers kits to assess DNA fragmentation (halosperm®), oxidative stress (oxiSperm®), and sperm membrane quality (vitalTest®).

The patient just needs to follow the doctor’s instructions. A semen sample is required and processed in the lab using a quick and simple protocol.
Halotech’s in vitro tests provide immediate results. Fragmentation and oxidation results are available in under an hour; vitality results are instant.

DNA Fragmentation (halosperm®): A non-invasive method analyzing ejaculated sperm. It distinguishes normal sperm (large chromatin dispersion halo) from damaged sperm (no halo).

Oxidation (oxiSperm®): Uses a reactive gel to detect color changes in fresh semen. A color scale determines oxidation level.

Vitality (vitalTest®): Differentiates live from dead sperm based on membrane integrity.

DNA fragmentation above 30% is considered high risk and suggests a male factor in reproductive failure.
DNA damage is multifactorial. Smoking, obesity, tight clothing, certain medications, fever, aging, chemotherapy, and radiation can increase fragmentation. Natural factors like improper maturation or oxidative stress also lead to damage during sperm production.

Many professionals use halotech® solutions early in treatment, alongside standard semen analysis. It’s especially recommended for:

  • Couples with recurrent miscarriages
  • Couples with unexplained infertility over 6 months
  • Men over 40
  • Men with cancer history
  • Men on prescription medication
  • Men exposed to toxins
  • Men with urogenital infections
  • Men with unhealthy lifestyles (smoking, poor diet, obesity, sedentary)
  • Poor embryo quality in donor egg cycles
  • Male factor infertility of unknown origin
Freezing semen in liquid nitrogen does not affect DNA fragmentation. Tests can be performed on frozen samples, which can later be used in ART. After thawing, samples should be used quickly to prevent further damage.

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Halotech® DNA based in Spain, Europe, is a leading international biotechnology company dedicated exclusively to the analysis of male and female fertility.

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Halotech® DNA
Spain, Europe
Biotech Company

+34 91 279 69 50

Halotech® DNA 2025, Spain, Europe

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