dyn-halosperm
7 de August de 2025
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PROFESSIONALS
WE ARE PIONEERS
IN DNA FRAGMENTATION
We strive for precision, speed, and rigor in genetic fertility diagnosis.
Our purpose is to support medical professionals in their decision-making process.
FERTILITY DIAGNOSTIC TESTS SCD PATENT DNA
Quality
Manufacturing
Established World
Distribution
Total Scientific Support
Easy, Simple
Application
OUR
PRODUCTS
Halosperm G2® PRO is the flagship product in our catalog. It offers a fast, simple, and cap-free method to measure sperm DNA fragmentation.
NUESTROS
PRODUCTOS
halosperm® G2 PRO es el producto estrella de nuestro catálogo. Proporciona un método rápido, sencillo y sin necesidad de usar una campana extractora, para medir la fragmentación del ADN espermático en tan solo 10 minutos.
WORLDWIDE DISTRIBUTION
Tenemos distribuidores y puntos de venta en más de 40 países, consúltanos.
Argelia
Argentina
Australia
Belarus
Bosnia
Brazil
Bulgaria
Chile
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Costa Rica
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Denmark
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Israel
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Tunes
Turkey
Ukraine
United Arab Emirates
United States
Uruguay
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Contact us
- Phone: (+34) 91 279 69 50
- General Information: info@halotechdna.com
- Technical Support: support@halotechdna.com
YOU'RE IN GOOD HANDS
Scientific Credits and Certifications
COMMON QUESTIONS
F.A.Q.
Why is the male factor important in fertility treatment?
A couple aged between 29 and 33 with no fertility issues has about a 20–25% chance of conceiving in any given month. After six months of trying, 60% of couples will conceive without medical help. If after one year of unprotected intercourse there is no pregnancy, the couple is considered infertile. The male factor accounts for 34% of infertility cases, while 30% involve both partners. That’s why a thorough semen analysis can help identify potential issues and avoid costly and repeated Assisted Reproduction Treatments (ART).
Does a standard semen analysis provide all the information about male fertility?
A standard semen analysis only evaluates sperm concentration, motility, and morphology. This is incomplete, as it does not assess one of the most important parameters: DNA integrity. Also, understanding oxidative stress levels and sperm membrane quality allows for a more accurate diagnosis for reproductive treatment. Around 15% of infertile men have normal semen analysis results.
How do DNA fragmentation, oxidation, and vitality affect male fertility?
DNA fragmentation, oxidative stress, and poor sperm vitality are directly linked to lower fertility and embryonic development failures. This leads to more ART cycles required to achieve pregnancy—whether through IUI, IVF, or ICSI—lower embryo quality, and higher rates of miscarriage.
What steps should I take after a diagnosis of fragmentation, oxidation, and low vitality?
Depending on the levels of DNA fragmentation, oxidation, and sperm vitality, the medical professional will assess the semen sample and, together with the standard semen analysis, determine the best reproductive technique and treatment to improve the chances of success.
Can these factors be reduced?
Antioxidant treatment can significantly reduce DNA fragmentation levels. The response depends on the root cause—if it’s due to toxic exposure or high temperatures triggering caspases and sperm endonucleases, it’s harder to modify sperm DNA fragmentation levels.
Are there techniques to obtain sperm with lower DNA fragmentation?
Sperm from the first fraction of the ejaculate typically has lower DNA fragmentation. Recurrent ejaculation or testicular sperm retrieval can also yield similar results depending on the patient. The effectiveness of these strategies should be evaluated by the medical professional.
Are semen analysis results consistent throughout a man’s life?
While semen quality may remain the same across different production and maturation cycles, it can also vary due to external factors like stress, infections, fever, or lifestyle changes. It’s important to assess the ejaculate quality used in ART.
How do ART outcomes vary based on whether or not these parameters are studied?
In IUI, pregnancy rates are nearly zero in men with DNA fragmentation levels above 30%. High fragmentation also indicates potential infections (e.g., Chlamydia trachomatis, Mycoplasma) or varicocele. Fragmentation above 30% impacts fertilization and embryo quality, leading to repeated miscarriages and lower reproductive success.
Does knowing the sperm DNA fragmentation increase the chances of treatment success?
Yes. DNA fragmentation is crucial in selecting the right ART strategy. Studies show that in IUI, fragmentation above 30% lowers the success rate from 19% to 1.5%. Knowing this, alternative techniques can be considered. In IVF, fragmentation below 25% leads to a 33% live birth rate, while over 50% drops that to 13%.
Are there existing techniques to assess sperm quality?
Halotech offers kits to assess DNA fragmentation (Halosperm), oxidative stress (Oxisperm), and sperm membrane quality (Vitaltest).
What’s the procedure like?
The patient just needs to follow the doctor’s instructions. A semen sample is required and processed in the lab using a quick and simple protocol.
How long do results take?
Halotech’s in vitro tests provide immediate results. Fragmentation and oxidation results are available in under an hour; vitality results are instant.
How do Halotech techniques work?
DNA Fragmentation (Halosperm): A non-invasive method analyzing ejaculated sperm. It distinguishes normal sperm (large chromatin dispersion halo) from damaged sperm (no halo).
Oxidation (Oxisperm): Uses a reactive gel to detect color changes in fresh semen. A color scale determines oxidation level.
Vitality (Vitaltest): Differentiates live from dead sperm based on membrane integrity.
What levels are considered normal?
DNA fragmentation above 30% is considered high risk and suggests a male factor in reproductive failure.
What causes sperm DNA damage?
DNA damage is multifactorial. Smoking, obesity, tight clothing, certain medications, fever, aging, chemotherapy, and radiation can increase fragmentation. Natural factors like improper maturation or oxidative stress also lead to damage during sperm production.
When is a sperm DNA fragmentation test recommended?
Many professionals use Halotech solutions early in treatment, alongside standard semen analysis. It’s especially recommended for:
- Couples with recurrent miscarriages
- Couples with unexplained infertility over 6 months
- Men over 40
- Men with cancer history
- Men on prescription medication
- Men exposed to toxins
- Men with urogenital infections
- Men with unhealthy lifestyles (smoking, poor diet, obesity, sedentary)
- Poor embryo quality in donor egg cycles
- Male factor infertility of unknown origin
Does cryopreservation affect semen samples?
Freezing semen in liquid nitrogen does not affect DNA fragmentation. Tests can be performed on frozen samples, which can later be used in ART. After thawing, samples should be used quickly to prevent further damage.
¿Por qué usar ovoselect®?
ovoselect® añade un nivel superior de seguridad a la evaluación de la calidad del ovocito, aumentando así el éxito en los resultados reproductivos.
¿Cuál es la base científica de ovoselect®?
ovoselect® se basa en el hecho de que las características de la cromatina de las Células del Cúmulo (CCs) en ovocitos inmaduros difieren significativamente de las observadas en ovocitos maduros.
Además, también pueden identificarse CCs que presentan núcleos con ADN fragmentado.
ovoselect® detecta y expone diferencias en las características de la cromatina de las Células del Cúmulo (CCs) en función del estado de calidad y madurez del ADN nuclear.
¿Por qué ovoselect® discrimina entre diferentes estados de cromatina de las CCs?
Las Células del Cúmulo son sensibles a cambios en las condiciones fisiológicas y ambientales, y especialmente a la estimulación hormonal. Se pueden observar genes expresados en las CCs y cambios morfológicos, en función del nivel de relajación de la cromatina. La relajación de la cromatina está relacionada con el nivel de actividad celular en las CCs.
Pueden observarse tres tipos de variaciones morfológicas tras el procesamiento con ovoselect®:
HCP: Células con Paquete de Cromatina Alto.
RC: Células con Cromatina Relajada.
D: Células con ADN Dañado (ver figura del flyer de ovoselect®).
Información proporcionada por ovoselect®
ovoselect® permite la visualización simultánea del estado de los tres tipos celulares utilizando las CCs asociadas a cada ovocito.
El nivel de daño en el ADN de las Células del Cúmulo (D) está relacionado con la competencia de los ovocitos para lograr un resultado reproductivo.
Tras la recuperación del ovocito, las CCs pueden clasificarse según el porcentaje de daño en el ADN observado en las CCs de cada ovocito individual. Los ovocitos que presentan un nivel más bajo de daño en el ADN de las CCs serán más competentes para la transferencia.
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halosperm G2
7 de August de 2025
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